We explore various techniques to incorporate grid-like layout conventions
into a force-directed, constraint-based graph layout framework. In doing so
we are able to provide high-quality layout---with predominantly axis-aligned
edges---that is more flexible than previous grid-like layout methods and
which can capture layout conventions in notations such as SBGN (Systems
Biology Graphical Notation). Furthermore, the layout is easily able to
respect user-defined constraints and adapt to interaction in online systems
and diagram editors such as Dunnart. Interactive use of our techniques is
demonstrated at \\url{http://youtu.be/b7nV8dvAlIc}.