Abstract:
We present a novel technique-Compressed Adjacency Matrices-for visualizing
gene regulatory networks. These directed networks have strong structural
characteristics: out-degrees with a scale-free distribution, in-degrees bound
by a low maximum, and few and small cycles. Standard visualization
techniques, such as node-link diagrams and adjacency matrices, are impeded by
these network characteristics. The scale-free distribution of out-degrees
causes a high number of intersecting edges in node-link diagrams. Adjacency
matrices become space-inefficient due to the low in-degrees and the resulting
sparse network. Compressed adjacency matrices, however, exploit these
structural characteristics. By cutting open and rearranging an adjacency
matrix, we achieve a compact and neatly-arranged visualization. Compressed
adjacency matrices allow for easy detection of subnetworks with a specific
structure, so-called motifs, which provide important knowledge about gene
regulatory networks to domain experts. We summarize motifs commonly referred
to in the literature, and relate them to network analysis tasks common to the
visualization domain. We show that a user can easily find the important
motifs in compressed adjacency matrices, and that this is hard in standard
adjacency matrix and node-link diagrams. We also demonstrate that interaction
techniques for standard adjacency matrices can be used for our compressed
variant. These techniques include rearrangement clustering, highlighting, and
filtering.